In case you missed it previously, Cabot Guns is building a left-hand oriented 1911 pistol called the South Paw. The South Paw was introduced at the 2012 SHOT Show.
Cabot claims the South Paw is the only left-handed 1911 pistol on the market, and I believe they are right. Left-handed firearms are often produced in limited numbers in the rifle community, but are even less common in handguns. Typically, gun companies will offer ambidextrous or reversible features (safeties, mag releases), but not a straight lefty.
The Charter Arms Southpaw, a left-handed .38 Special revolver, is another example of a left-handed handgun.
According to Cabot Guns, the South Paw is a precision handgun machined to “extreme tolerances.” The price? $5250.